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Dynamics analysis of bladder-urethra system based on CFD

Qinghua JIN, Xiaojun ZHANG, Xiaoyang LI, Jianliu WANG,

《机械工程前沿（英文）》 2010年 第5卷 第3期   页码 336-340 doi: 10.1007/s11465-010-0027-8

摘要： A mathematical model for a bladder-urethra system can provide basic analysis for the disabled urethra closure of stress urinary incontinence (SUI) patients in a clinic. Based on computational fluid dynamics (CFD), we developed a three-dimensional urodynamic bladder-urethra system, which includes bladder, bladder neck, prostate, and urethra. The realistic recirculation process of the urinary bladder during the physiologic voiding process in conjunction with a flow simulation through the female urinary bladder and urethra is presented. The computational results show that a dead-water zone and the zone of secondary flow occur, independent of the shape of the prostatic urethra. For the pathological prostata, the extreme constriction of the prostatic urethra results in an additional wide-stretched dead-water zone. The simulation results does not only improve urinary incontinence surgery for clinicians, but can also provide a basis for theoretical analysis.

关键词： bladder-urethra system     stress urinary incontinence (SUI)     computational fluid dynamics (CFD)     urodynamics    

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Small cell carcinoma of the urinary bladder without gross hematuria: a case report

null

《医学前沿（英文）》 2015年 第9卷 第3期   页码 384-387 doi: 10.1007/s11684-015-0405-z

摘要：

Small cell carcinoma of the urinary bladder (SCCB) is a rare and aggressive form of bladder cancer with poor prognosis. Hematuria is the main symptom of this malignancy, and most patients have a history of smoking. The disease incidence of malignant bladder tumors in China is approximately 0.74%. Early and accurate diagnosis of SCCB can ensure timely and appropriate treatment of this malignant disease. Oncologic surgery is the standard treatment; however, it may not be a curative approach. Chemotherapy and/or radiotherapy should be performed following surgical removal. This case report describes a patient with a single neoplasm diagnosed as SCCB that arose because of recurrence of bladder cancer after bladder tumor resection. In contrast to previously reported cases, this patient had no gross hematuria and no history of smoking.

关键词： carcinoma     small cell     urinary bladder neoplasms     diagnosis    

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Can intravesical bacillus Calmette-Guérin reduce recurrence in patients with non-muscle invasive bladder

null

《医学前沿（英文）》 2014年 第8卷 第2期   页码 241-249 doi: 10.1007/s11684-014-0328-0

摘要：

Approximately 70% of newly diagnosed bladder tumors are non-muscle invasive bladder cancer (NMIBC). NMIBC accounts for approximately 80% of total bladder cancer cases. Bacillus Calmette-Guérin (BCG) instillation and maintenance is considered as the standard adjuvant treatment for superficial bladder cancer. A number of randomized studies have focused on the benefit of maintenance therapy following initial BCG induction. To provide further insights into the effect of intravesical instillation on recurrence in patients with NMIBC, we analyzed this relationship by conducting an updated detailed meta-analysis. Evidence suggested that adjuvant intravesical BCG with maintenance treatment is significantly effective for the prophylaxis of tumor recurrence in patients with NMIBC.

关键词： non-muscle invasive bladder cancer     bacillus Calmette-Guérin (BCG)     meta-analysis    

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A comparative study of electroacupuncture at Zhongliao (BL33) and other acupoints for overactive bladder

null

《医学前沿（英文）》 2017年 第11卷 第1期   页码 129-136 doi: 10.1007/s11684-016-0491-6

摘要：

Electroacupuncture (EA) at Zhongliao (BL33) can improve the symptoms of overactive bladder (OAB), such as urinary frequency, urgency, and incontinence. However, its performance compared with other acupoints remains unclear. This study investigated the effects of EA at BL33 with deep needling on rats with OAB by detecting urodynamics in eight groups: no intervention group, D-BL33 group (deep needling at BL33), S-BL33 group (shallow needling at BL33), non-acupoint group (needling at the non-acupoint next to BL33), Weizhong (BL40) group, Sanyinjiao (SP6) group, Tongtian (BL7) group, and Hegu (LI4) group. Results revealed that EA at BL33 with deep needling, BL40, and SP6 prolonged the intercontraction interval (ICI) of rats with OAB (P=0.001, P=0.005, P=0.046, respectively, post-treatment vs. post-modeling). Furthermore, the change in ICI from post-modeling in the D-BL33 group was significantly greater than those of the no intervention and other EA groups (all P<0.01). Significantly shortened vesical micturition time (VMT) and elevated maximum detrusor pressure (MDP) were also observed in the D-BL33 group (P=0.017 and P=0.024, respectively, post-treatment vs. post-modeling). However, no statistically significant differences in the changes of VMT and MDP from post-modeling were observed between D-BL33 and the other EA groups. In conclusion, EA at BL33 with deep needling may inhibit acetic-acid-induced OAB more effectively.

关键词： overactive bladder     electroacupuncture     acupuncture points    

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randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against recurrence of T1G3 bladder

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

《医学前沿（英文）》 2008年 第2卷 第3期   页码 259-263 doi: 10.1007/s11684-008-0049-3

摘要： Meta-analysis was used to determine whether maintenance intravesical bacillus Calmette-Guerin (BCG) could reduce recurrence after transurethral resection of tumor 1 grade 3 (T1G3) superficial bladder cancer. All available published data of randomized clinical trials comparing transurethral resection plus intravesical BCG to either resection alone or resection plus another treatment on the treatment results in patients with superficial bladder cancer of T1G3 were selected for analysis. Both the fixed effects model and random effects model were applied, and the odds ratio () with its 95% confidence interval (CI) was used as the effect size estimate. Sensitivity analysis and publication bias determination were performed by funnel plots and comparing s of different models. Within the follow-up period, 375 of 915 (41.0%) BCG-treated patients and 332 of 733 (45.3%) non-BCG-treated patients developed tumor recurrence. In the combined results, a statistically significant difference in the s for tumor recurrence between the two treatment groups was found (randomized model combined effect 0.58, 95% CI 0.41 to 0.83, = 0.003). The stratified meta-analysis did not show any statistically significant confounding effects on the results when stratified by BCG strains. The randomized model combined effect of Pasteur F and other strains were 0.50 (95% CI 0.26 to 0.95, = 0.04) and 0.63 (95% CI 0.40 to 0.99, = 0.04), respectively. Therefore, we came to the conclusion that adjuvant maintenance instillation BCG combined with transurethral resection of bladder tumor (TURBT) is an effective conservative treatment for preventing recurrence of T1G3 bladder cancer.
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Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder

FAN Xiaodong, HAN Ruifa

《医学前沿（英文）》 2007年 第1卷 第4期   页码 377-380 doi: 10.1007/s11684-007-0073-8

摘要： Presently, one of the most potent immunotherapies is the application of bacillus Calmette Guerin (BCG) to prevent recurrences of the superficial bladder cancer. Despite its successful use, nonresponders and certain side effects remain a major obstacle. Therefore, current studies aim at developing recombinant BCG (rBCG) strains secreting Th1-like cytokines to improve the effectiveness of the therapy. In this study, a new type of rBCG strain constructed by Tianjin institute of Urology was tested for its immunostimulatory capacity . Peripheral blood monocytes (PBMC) were stimulated by recombinant BCG and transformed into bacilli Calmette–Guerin activated killer (BAK) cells, and the effect of anticancer BAK cells was studied. Recombinant IFN--2b-BCG, wild-type BCG (wBCG), wild-type BCG and IFN--2b were coincubated with PBMCs respectively , and the proliferation of PBMC was detected with MTT in different time. BAK cells have the ability to kill bladder tumor cells, and the antitumor activity of effecter cells was determined by LDH release assay. The result of MTT showed that the proliferation of PBMC in the recombinant BCG group was more powerful than in the other two groups (<0.05). The result of LDH release assay showed that the antitumor activity of BAK cells stimulated by Recombinant BCG was the highest in all groups. We conclude that the recombinant BCG can activate more PBMCs to anti-bladder cancer than wild-type BCG does.

关键词： Urology     powerful     2b-BCG     Tianjin institute     wild-type    

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Preliminary clinical study on non-transecting anastomotic bulbomembranous urethroplasty

null

《医学前沿（英文）》 2017年 第11卷 第2期   页码 277-283 doi: 10.1007/s11684-017-0515-x

摘要：

This study aims to investigate the effect of non-transecting anastomotic urethroplasty for treatment of posterior urethral stricture. A total of 23 patients with traumatic posterior urethral stricture were enrolled and then divided into two groups. In one group, 12 patients underwent non-transecting anastomotic urethroplasty. In the other group, 11 patients underwent conventional posterior urethra end-to-end anastomosis. The effect of operation was evaluated using the following parameters: the bleeding amount during operation, operation time, IIEF-5 scores after operation, maximum flow rate (Qmax), and rating scale of quality of life (QoL). The comparison between the conventional posterior urethra end-to-end anastomosis group and the non-transecting anastomotic urethroplasty group showed no significant difference with regard to average operation time. However, a significant difference was observed between the groups with regard to the bleeding amount during operation. The patients in the group of non-transecting anastomotic urethroplasty urinated smoothly after the removal of catheter. Meanwhile, one patient from the group of conventional posterior urethra end-to-end anastomosis had difficulty urinating after the removal of catheter. Furthermore, significant differences in the operation time, bleeding amount during operation, IIEF-5 scores after operation, and rating scale of QoL were observed, whereas no significant difference was observed between urine flow rates of the two groups after operation. Overall, non-transecting anastomotic urethroplasty is effective for posterior urethra reconstruction, and it can reduce the occurrence rate of erectile dysfunction after operation.

关键词： anastomotic urethroplasty     transecting     posterior urethra reconstruction    

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Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

《医学前沿（英文）》 2009年 第3卷 第2期   页码 197-203 doi: 10.1007/s11684-009-0036-3

摘要： The mRNA and protein expression of phosphatase of regenerating liver 1 (PRL-1) and phosphatase of regenerating liver 3 (PRL-3) in transitional cell carcinoma of bladder (BTCC) and normal epithelia of bladder was investigated, and the relationship between the BTCC and pathological changes was clarified. The expression of PRL-1 and PRL-3 mRNA was detected by using reverse transcription polymerase chain reaction (RT-PCR) in 30 cases of BTCC and 10 cases of normal bladder, and the expression of PRL-1 and PRL-3 protein was checked by using immunohistochemistry in 30 cases of BTCC and 15 cases of normal bladder. The expression levels of PRL-1 and PRL-3 mRNA and protein were higher in BTCC than those in normal bladder epithelia ( <0.05). The increased expression of PRL-1 and PRL-3 mRNA and protein was detectable in deep invasion and metastasis of BTCC ( <0.05). There was no correlation between the expression of PRL-1 and PRL-3 and gender, age or recurrence of BTCC (all >0.05). A significantly positive correlation was found between PRL-1 and PRL-3 in BTCC ( <0.05). PRL-1 and PRL-3 are expressed consistently and may contribute to the growth, differentiation, invasion and metastasis of BTCC.

关键词： transitional cell carcinoma of bladder     phosphatase of regenerating liver 1     phosphatase of regenerating liver 3     reverse transcription polymerase chain reaction     immunohistochemistry    

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医疗保健中的人工智能——综述与预测性案例研究 Review

荣国光, Arnaldo Mendez, Elie Bou Assi, 赵博, Mohamad Sawan

《工程（英文）》 2020年 第6卷 第3期   页码 291-301 doi: 10.1016/j.eng.2019.08.015

摘要：

近年来，人工智能在软件算法、硬件实现和应用等领域得到了迅速发展。本文综述了人工智能在生物医学中应用的最新进展，包括疾病诊断、生活辅助、生物医学信息处理和生物医学研究。综述的目的是跟踪新的科学成就，了解人工智能在生物医学中的巨大潜力和相关技术的适用性，并为相关领域的研究人员提供启示。可以断言，正如人工智能本身一样，人工智能在生物医学中的应用尚处于早期阶段。新的进展和突破将继续推进，不断深入并扩大广度，并在不久的将来迅速发展。本文以人工智能在癫痫发作和膀胱功能失调预测方面的应用的两个案例来说明其在生物医疗等方面的应用。

关键词： 人工智能     机器学习     深度学习     神经网络     生物医学研究     医疗保健应用     癫痫发作     膀胱充盈    

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System reliability and system resilience

《工程管理前沿（英文）》 2021年 第8卷 第4期   页码 615-619 doi: 10.1007/s42524-021-0176-y

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工程 工程系统 工程系统论与工程科学体系

王连成

《中国工程科学》 2001年 第3卷 第6期   页码 15-18

摘要：

从分析工程的基本内容、性质和特征人手，引出了工程系统的概念，接着应用一般系统论思想讨论了工程系统论的研究对象和研究方法，并论述了它在整个工程科学体系中的元学科地位。

关键词： 工程     系统     系统论     学科    

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Cyber–Physical Power System (CPPS): A review on measures and optimization methods of system resilience

《工程管理前沿（英文）》 2021年 第8卷 第4期   页码 503-518 doi: 10.1007/s42524-021-0163-3

摘要： The Cyber–Physical Power System (CPPS) is one of the most critical infrastructure systems in a country because a stable and secure power supply is a key foundation for national and social development. In recent years, resilience has become a major topic in preventing and mitigating the risks caused by large-scale blackouts of CPPSs. Accordingly, the concept and significance of CPPS resilience are at first explained from the engineering perspective in this study. Then, a review of representative quantitative assessment measures of CPPS resilience applied in the existing literature is provided. On the basis of these assessment measures, the optimization methods of CPPS resilience are reviewed from three perspectives, which are mainly focused on the current research, namely, optimizing the recovery sequence of components, identifying and protecting critical nodes, and enhancing the coupling patterns between physical and cyber networks. The recent advances in modeling methods for cascading failures within the CPPS, which is the theoretical foundation for the resilience assessment and optimization research of CPPSs, are also presented. Lastly, the challenges and future research directions for resilience optimizing of CPPSs are discussed.

关键词： Cyber–Physical Power System     resilience assessment     resilience optimization     cascading failure modeling    

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Discussion on the System Optimization of the Energy Development Strategy and Plan

Da-di Zhou

《工程管理前沿（英文）》 2014年 第1卷 第2期   页码 147-152 doi: 10.15302/J-FEM-2014022

摘要： Energy is an important basis for economic and social development, and is a critical economic sector. Due to the complexity of the energy system, the interactive relationship with economic and social development, and the enormous investment involved, the optimization of the energy system is of great significance. We should make efforts to develop targets and specific approaches for the rational and optimal development of an energy system in order to avoid big losses due to systematic mistakes.

关键词： energy development strategy     planning system     system optimization    

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Distributed monitoring and diagnosis system for hydraulic system of construction machinery

Xiaohu CHEN, Wenfeng WU, Hangong WANG, Yongtao ZHOU,

《机械工程前沿（英文）》 2010年 第5卷 第1期   页码 106-110 doi: 10.1007/s11465-009-0089-7

摘要： This paper mainly presents a distributed monitoring and diagnosis system for the hydraulic system of construction machinery based on the controller area net (CAN) field bus. The hardware of the distributed condition monitoring and fault diagnosis system is designed. Its structure including the sensors, distributed data acquisition units, central signal processing unit, and CAN field bus is introduced. The software is also programmed. The general software design and its realization are studied in detail. The experiments and applications indicate that the distributed condition monitoring and fault diagnosis system can effectively realize its function of real-time online condition monitoring and fault diagnosis for the hydraulic system of construction machinery.

关键词： construction machinery     hydraulic system     distributed condition monitoring     controller area net (CAN) field bus     fault diagnosis    

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Theory and method of mechanism system design

Huijun ZOU, Qinghua LIANG, Qing ZHANG

《机械工程前沿（英文）》 2010年 第5卷 第4期   页码 399-411 doi: 10.1007/s11465-010-0116-8

摘要： Conceptual design is the most critical and creative phase of design. Recently, increasing attention has been directed to supporting conceptual-level computer aided creative design and its theories and methodologies. Specifically, for conceptual design of mechanical products, this paper presents a novel function solving model for mechanical product design and highlights the importance of systematic synthesis to achieve creative design. Then it builds a framework as a function-effect-process-action- mechanisms (FEPAM) mapping process, which enables creative design on the basis of conceiving different action schemes. After that, several key points are elaborated including 1) representing and decomposition methods of functions and motion behaviors; 2) action scheme representing method based on network plan techniques; and 3) variation and creation methods based on action scheme transformations.

关键词： mechanism system creative design     process model     function solving model     process action procedure     mechanisms knowledge base     principle of mechanism system composition    

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标题 作者 时间 类型 操作

Dynamics analysis of bladder-urethra system based on CFD

Qinghua JIN, Xiaojun ZHANG, Xiaoyang LI, Jianliu WANG,

期刊论文

Small cell carcinoma of the urinary bladder without gross hematuria: a case report

null

期刊论文

Can intravesical bacillus Calmette-Guérin reduce recurrence in patients with non-muscle invasive bladder

null

期刊论文

A comparative study of electroacupuncture at Zhongliao (BL33) and other acupoints for overactive bladder

null

期刊论文

randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against recurrence of T1G3 bladder

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

期刊论文

Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder

FAN Xiaodong, HAN Ruifa

期刊论文

Preliminary clinical study on non-transecting anastomotic bulbomembranous urethroplasty

null

期刊论文

Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

期刊论文

医疗保健中的人工智能——综述与预测性案例研究

荣国光, Arnaldo Mendez, Elie Bou Assi, 赵博, Mohamad Sawan

期刊论文

System reliability and system resilience

期刊论文

工程 工程系统 工程系统论与工程科学体系

王连成

期刊论文

Cyber–Physical Power System (CPPS): A review on measures and optimization methods of system resilience

期刊论文

Discussion on the System Optimization of the Energy Development Strategy and Plan

Da-di Zhou

期刊论文

Distributed monitoring and diagnosis system for hydraulic system of construction machinery

Xiaohu CHEN, Wenfeng WU, Hangong WANG, Yongtao ZHOU,

期刊论文

Theory and method of mechanism system design

Huijun ZOU, Qinghua LIANG, Qing ZHANG

期刊论文